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Pulmonary & Critical Care Bulletin
Vol. VII, No. 3, July 15, 2001 |
In this issue : From Editor's Desk
AEROSOL THERAPY
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ONCE - DAILY ASTHMA PREVENTION THERAPY
Because of socio - economic factors, adverse drug reactions, complexity of regimens and prolonged ( or life - long ) therapy, over half of asthma patients fail to take their medication regularly. Compliance with 'anti-inflammatory' or ' preventive' therapy is particularly important, as its early initiation helps in preventing disease progression. Likelihood of improved compliance is strong with once daily dose schedules.
(a) Once - daily inhaled corticosteroids
Once daily inhaled corticosteroids should be prescribed in the evening since there is increasing evidence that mechanisms of inflammation are under circadian control. Many patients experience particularly troublesome symptoms at night and in the early morning. Bronchial smooth muscle hyper-responsiveness varies in a circadian fashion and is enhanced at night. The clinical relevance is that better asthma control might be achieved by evening dosing, so that rising drug levels coincide with the natural peak in airways inflammation.
(B) Oral corticosteroids R. S. Bedi & U.S. Bedi
R. S. Bedi & U.S. Bedi |
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