|Indmedica Home | About Indmedica | Medical Jobs | Advertise On Indmedica|
Pulmonary & Critical Care Bulletin
Vol. VII, No. 3, July 15, 2001
In this issue :
From Editor's Desk
Newer Antimicrobials - Antifungals and Antibacterials
A. Antibacterials :
I. New fluoroquinolones
a. Extended spectrum penicillins
B. Newer Antifungals
I. Lipid formulation of ambphotericin -B
I. New Fluoroquinolones (FQ)
Basic structure of quinolones involves 4-quinolone nucleus. It is by modifications of the basic nucleus by which we get various generations of flouroquinolones
Therapeutic uses of 3rd & 4th Generation - FQs
1. Role in Community Acquired Pneumonia: 3rd and 4th generations FQs because of their spectrum include almost all the organisms causing community acquired pneumonia - so they are agents of choice for treatment of community acquired pneumonias. But it is strongly recommended that their use should be limited to those 20% cases of community acquired pneumonia who are acutely and severely ill requiring hospitalization. Rest of 80% of patients being treated as outdoor patients should be given some less potent agents. This is because of concerns regarding emergence of drug resistance strains if these agents are indiscriminately used.
2. Role in Nosocomial Pneumonia: Because pseudomonas are not included in spectrum so they cannot be relied upon as single agents for treatment of nosocomial pneumonia.
3. Role as antimycobacterial : Levofloxacin has been used in dosage ranging from 500 mg to 1000 mg as an anti TB agent and has been found to be superior to ofloxacin.
4. Role in transitional therapy: (Change from parenteral to enteral) Third and 4th generation FQs form excellent agents for transitional therapy because of the following : (I) Both oral / parenteral forms are available (ii) Bioavailability after oral route is high and high concentration in plasma/tissue/body fluids is achieved (iii) Rapid bactericidal action.
5. Role in combination chemotherapy: Antipseudomonas beta lactam combined with aminoglycosides produce more frequently synergistic action against pseudomonas than fluoroquinolones combined with aminoglycosides.
Side effects :
i. Phototoxicity - Decreasing order of phototoxicity with Sport. >Lomef >Clinaf. > Trovaf. Not reported with Gatiflox and Trovafloxacin.
None of the 4th generation FQs are available in India at present.
II. Glycoprotein Antibiotics: include vancomycin and teichoplanin
Advantages of Teichoplanin over vancomycin :
i. Half life long so single daily dose possible/vancomycin has to be given bid/quid.
Disadvantages of Teichoplanin
i. No oral formulation is available so vancomycin is drug of choice for pseudomembranous colitis.
III. Beta Lactams:
(a) Extended Spectrum Penicillins:
Piperacillin and Tazobactam Sodium is an injectable antibacterial combination of piperacillin sodium and tazobactum sodium (Beta Lactamase inhibitor)
Indications are very specific -
i. Community acquired pneumonias caused by piperacillin resistant beta lactamase producing strains of H. influenzae.
ii. Nosocomial pneumonias caused by beta lactamase producing strains of Staph. aureus
For nosocomial pneumonias - caused by pseudomonas, it must be combined with aminoglycoside because tazobactam sodium inhibits only plasmid mediated beta lactamase products while beta lactamase producing isolates of pseudomonas are chromosomally derived and are not sensitive.
Dosage: Daily adult dose is 12 g/1.5 g by slow i.v., 4 divided dosages.
b) Carbapenems : Include Cilstatin Imepenem combination and Meropenem. Carbapenems are broad spectrum antibacterials covering against : i. Gram +ve including staph (except MRSA), ii. Gram neg. aerobes including pseudomonas, iii. Gram +ve and neg. anaerobes.
i. LRTI caused by staph (Penicillinase + ve), E. coli, klebsiella, enterobecter sp, H. influenzae;
Menopenems - Advantages over cilstatin - Imipenam combination
i. No drug interaction with ganciclovir
c) Cephalosporins - i. Cefpodoxime proxetil (3rd gen.; oral)
Cefpodoxime proxetil is a prodrug, absorption increases when taken with food. Spectrum is broad, includes gram, neg. organism including moderate activity against Staph aureus.
Clinical use - comparative studies have shown it to be a good agent for mild to moderate cases of community acquired pneumonia and acute exacerbation of chronic bronchitis.
ii. Cefepime - 4th generation broad spectrum parenteral compound approved by FDA in 1996.
1. Moderate to severe pneumonia caused by gram neg. organisms including Ps. aeruginosa (1-2 g i.v. 12 hourly)
2. Empiric therapy for febrile neutropenic patients (2 g. i.v. 8 hrly) for seven days or till neutropenia persist.
Availability - Not available in India.
d) Monobactams - Aztreonam belong to the group. It has two peculiar features.
Availability - Not available in India.
i. Lipid formulations for ambphotericin B (Am B) - Lipsosomal technology was introduced in the late 1970s with the purpose of increasing drug delivery at the site of action. But when applied to polyene antifungals it was found to decrease nephrotoxicity appreciably.
Currently, 3 lipid forms are available depending upon the type of lipid and their arrangement.
a. ABLC (AmB Lipid complex)
Clinical use - indicated in patients who have renal toxicity due to conventional AmB therapy or who fail to conventional AmB.
Availability : Ambisome and ABCD are available in India. Cost of treatment is very high - Rs. 35000 - Rs. 45000/- per day
ii. News Azoles - include - ZD 0870
Voriconazole is a derivative of fluconazole. It is 4-16 times more active than fluconazole and 2-8 fold more active than itraconazole againt candida cruzei and glabrata. It is 160 times more potent than fluconazole in inhibiting cell membrane enzymes of Aspergillus fumigatus. It has good in vitro activity against isolates of aspergillus which are resistant to AmB.
Current status : Voriconazole is in phase III trials while other azoles are in phase I and phase II trials.
Investigational antifungals include :
- Echinocardins and related peptides - Cyclic depsipeptides
Dr. Surinder Mahajan, Senior Resident,
Dr. Surinder Mahajan, Senior Resident
About Us |
All Specialities |
Medical Jobs |
Medical Admissions |
Medical/Dental/Pharmacy/Nursing/Homoeopathy Colleges |
Equipment Suppliers |
Pharmaceuticals | Blood Banks | STD Clinics | Contact Us
| Copyright 2005 Ind Medica
Pvt. Ltd. All Rights Reserved. Terms and Conditions
Last updated : 16-Dec-18|