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Current Pediatric Research

Frequency of complications of persistent rhinorrhoea in children

Author(s): Seema Sharma, Ashwani Sood, Dipty Jain

Vol. 13, No. 1 (2009-01 - 2009-12)

Seema Sharma, Ashwani Sood, Dipty Jain٭

Department of Pediatrics, Indira Gandhi Medical College and Hospital Shimla (HP), India
٭Government Medical College and Hospital Nagpur (M.S.), India

Abstract

This study was performed to determine the frequency of complications (pharynigtis / tonsillitis/ sinusitis / otitis media) in children with persistent rhinorrhoea. Methods: Children aged 6 months to 12 years were enrolled as per inclusion criteria and follow up examination was done on day 3 and day 10. Tympanometry was done on 30th day to assess impedance hearing impairment. The rate of complications was compared between children with persistent rhinorrhoea and those with acute rhinorrhoea. Reults: Out of 222 patients with persistent rhinorrhoea, 152 (68.5%) had pharyngitis, 47(21.2%), had tonsillitis, 79 (35.6%) had otitis media, 65 (29.2%) had lymphadenitis, 11 (5.0%) had sinusitis, 13 (5.9%) had acute lower respiratory tract infection (LRTI).Conclusion: The study demonstrated that children with persistent rhinorrhoea have significantly higher level of complications than patients with acute rhinorrhea. Hence, it is important to to identify these children with high risk for complications.

Key words: Otitis media; Pharyngitis ;Rhinorrhoea; Sinusitis.

Accepted January 12 2009

Introduction

Persistent rhinorrhoea (running nose) is a common outpatient problem in children. The course of action varies from observation to antibiotics. Ballenger [1] states that secondary bacterial invasion may occur which prolongs the illness for 6 to 8 days, hence the purulence represents a complication of clear rhinorrhoea. Fergerson and Kendig [2] suggested that a secondary purulent bacte- rial rhinitis may follow a viral rhinitis. Review of available literature revealed no clinical trials to substantiate the suggested treatment. The major events predisposing to the developments of complications like pharyngitis, tonsillitis, sinusitis, otitis media, lower respiratory tract infections (LRTI) are viral upper respiratory tract infection (URTI) and allergic inflammation. The frequency with which viral URTI in children is complicated by secondary bacterial infections has not been estimated/documented. This study was undertaken to determine the frequency of complications of such respiratory tract infections in children.

Materials and Methods

A cohort study was planned to compare the frequency of complications in children with persistent rhinorrhoea and acute rhinorrhoea. Children aged 6 months to 12 years of age attending OPD with rhinorrhoea were enrolled over one year. These children were divided in two groups; Group A and B. To qualify for the enrollment the subjects must have acute rhinorrhoea of <2days for group A (less exposed group) and persistent rhinorrhoea of >10 days for group B (more exposed group) with a history of wellness prior to enrollment. To begin with 500 patients were en- rolled, 250 in each group. Children with h/o antibiotics administration within 48 hours, with craniofacial anomalies, illnesses requiring hospitalization or any other serious illness were excluded. Data was collected on age, sex, reason for seeing the physician, duration of nasal discharge prior to visit, presence of fever and medications used.

The children enrolled were subjected to complete physical and systemic examination including ENT examination by two residents each one from Paediatrics and ENT Department. All the patients were followed up on day 3, 10 and 30th. Tympanometry was done on 30th day to find out the impedance hearing impairment in patients who had abnormal tympanic membrane. Normal tympanogram demonstrate good mobility (compliance of middle ear system) with peak pressure at ambient atomosphere pressure while abnormal tympanogram is just flat without any pressure peak or measurable compliance. Oral consent was taken from parents/caregivers of every patient. Due clearance was taken from ethical committee for conducting this study. Sharma/ Jain

A simple rhinorrhoea was taken as the presence of clear nasal discharge whereas complicated rhinorrhoea was taken as rhinorrhoea associated with pharyngitis, tonsillitis, sinusitis, otitis media, LRTI. Pharyngitis was taken as congestion of pharyngeal wall. Tonsillitis was defined as congestion along with parenchymatous or follicular tonsillitis. Sinusitis was defined as facial or paranasal tender- ness. Otitis media was defined as presence of abnormal tympanic membrane on otoscopic examination; presence of drainage from either ear during follow up period and abnormal tympanometry on 30th day. Patient is said to have acute LRTI if there was tachypnea; rales wheezing cyanosis; and/or chest indrawing. Complications were appropriately managed as indicated and if infection was suspected then appropriate antibiotic started.The complications in the two groups were compared using using X2 test.

Results

Both the groups were comparable for sex, age and socio economic status. At enrollment there were 250 patients in group A and 250 patients in group B (Table I). Majority of children in both the groups were between the age group of 6 months to 5 yrs, 171 (68.5%) in group A and170(68%) in group B. In group A 104(41.6%) patients were from upper lower class and 75 (30.1%) were from lower middle class whereas in group B 106(42.5%) patients were from upper lower and 79 (31.5%) patients were from lower middle class (Modified Kuppuswamy scale). 31(12.4%) patients from group A and 28(11.2%) patients from group B were lost to follow-up, hence excluded from the study. There was good correlation between both the residents in correlating symptoms and complications (Kappa statistics 0.75).

Table I: The summary of clinical history and Complications

Sr No. Symptoms Gp A
n=250(%)
Gp B
n=250(%)
p-value
1 Type of nasal discharge;
Clear
Mucoid
Purulent

216(86.3)
23(9.1)
11 (4.5)

96(38.3)
76(30.5)
77(31.0)

0
0
0
2 Sore throat 88 (35.1) 178(71.2) 0
3 Otitis media 11 (4.5) 42 (16.9) 0
4 Retrobulbar headache 05 (1.8) 15 (5.9) 0.022
(Fischer exact test)
5 Lymphadenopathy
(jugu-lodiagastric)
18 (7.3) 80(31.9) 0
6 Ear ache 03 (0.9) 33(13.2) 0
(Fischer exact test)
7 Noisy breathing 21 (8.2) 62(24.7) 0
8 Cough 91 (36.5) 183(73.0) 0
9 Sleeping disturbances 18 (7.3) 65(26.0) 0
10 Activity changes 63 (25.1) 100(40.2) 0
11 Appetite disturbances 57 (22.8) 127(50.7) 0
12 H/O Smoke in family 156 (62.5) 135(53.9) 0.656 (NS)٭
Sr No. Complications Group A n=219(%) Group B n=222(%) p-value
1. Pharyngitis 76 (34.70) 150(68.49) 0
2 Tonsilitis 13(5.94) 48(21.91) 0
3 Otitis media 10(4.52) 78(35.62) 0
3a Secretory OM 06(2.74) 27(12.33) 0
3b Suppurative OM 03(1.37) 41(18.72) 0
3c Perforated TM 01(0.46) 10(4.52) 0.005
4 Sinusitis 04(1.83) 11(5.02) 0.065 (NS)
5 Acute LRTI 14(6.39) 13(5.94) 0.842 (NS)4

٭Not significant

The total number of complications were higher in children with persistent rhinorrhoea as compared to children with acute rhinorrhoea (TableI). The pattern of complications was observed to be same even during follow up examinations. 4(1.8%) patients in group A and 22 (9. 1%) patients in group B had abnormal tympanogram on 30th day (p=<0.001).

Discussion

The subset of patients of rhinorrhoea with prolonged symptoms may be a group who probably develops bacterial super-infection and are at a greater risk to develop frequent and severe complications [3,4]. There are also problems related to liberal use of antibiotics in children with acute respiratory infections like emergence of antimicrobial resistance which is directly proportional to the extent of antibiotic use in the community [5]. Therefore, it is essential to carefully weigh the benefits from the antibiotic usage against the problems associated with widespread antibiotic misuse.

The purulent nasal discharge may be because of probable bacterial super-infection in patients with persistent rhinorrhoea. The association of pharyngitis and tonsillitis could be because of blocked nose, due to which a child breathes through mouth and develops a sore throat [6].

The otitis media with effusion (OME) in URTI is due to hypo-function of the Eustachian tube, leading to collection of fluid which contains bacteria and polymorphonuclear leukocytes, in the middle ear thus contributing to OME [7,8,9] The rate of OME (35.6%) in our study was higher than the study reported by Wald, Guerra NK, and Byers [10] where (29.2%) ARI were complicated by OME. The higher rate in our study could be because of greater risk of over-crowding, poor living conditions and personal hygiene, malnutrition and higher rate of bacterial carriage

In the present study 5.0% patients had sinusitis which was in comparison with other studies who have reported acute sinusitis as a complication of common cold in 0.5 to 5% of patients [10,12]. The presence of acute sinusitis may be because of mucosal inflammation which may lead to obstruction of the sinus cavities. Without proper drainage bacteria that are part of the normal upper respiratory tract flora can be trapped and proliferate and results into acute sinusitis [13]

The overall complication rate 28.8% was higher in patients with persistent rhinorrhoea as compared to 15% reported by Wald ER [14]. The complication rate in group B was observed to be higher than the group A on follow up examination, probably because of chronic rhinosinusitis in group B.

Tympanometry was done to find out impedance deafness. The persistence of secretion in the middle ear cavity following the allergic rhinitis may compromise the normal function of the ossicular chain and thus the transmission of sounds, leading to the onset of hypoacusis which may interfere negatively with child’s mental and physical development [15]. Limitations of this study include difficulty in assessment of clinical signs like sinusitis in younger children and inability of isolation of viruses and culturing individual organisms.

Conclusion

Physicians caring for children see rhinorrhoea in everyday practice, and this clinical entity currently has multiple recommendations regarding management. This study demonstrated that the children with persistent rhinorrhoea constitute a risk group hence it is important to be able to distinguish this group of children. The complications in high risk group may be responsible for school absenteeism and poor scholastic performance3. Impedance deafness seems to be unfavorable for child’s development hence adequate attention should be paid to the duration of symptoms and occurrence of complications and efforts should be made to minimize these.

After better elucidation of the complication rate in children with persistent rhinorrhoea along with reasonable theoretical and clinical evidence, antibiotic intervention for persistent rhinorrhoea may be effective in improving clinical out comes resulting in overall improvement of child health worldwide.

Further, long term controlled trials spread over multicenters are suggested.

References

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  2. Fergerson CF, Kendig EL. Disorders of the respiratory tract in children.2nd Ed PhiladelphiaWB Saunders Publishers and Distributers 1972; 2: 982.
  3. Bahram Mirsaid Ghazi, Ramin Imamzadehgan .Frequency of allergic rhinitis in school-age children (7-18 years) in Tehran. Iranian Journal of allergy, asthma and Immunology 2003;vol 2 no. 4: 181-184.
  4. Lisa M Shroeder .Common Cold:In: The 5 minute clinical consult. Lippincott Williams and Wilkins 2007; 284-285
  5. Green RJ. Symptomatic treatment of upper respiratory tract symptoms in children. SA Fam Pract 2006; 48: 38-42.
  6. Carne S.Care of children in general practice. BMJ 1979; 2: 190-192.
  7. Bylander A. Upper respiratory tract infection and Eustachian tube function in Children. Acta Otolaryngolol 1984; 97: 343-349.
  8. Henderson FW, Giebink GS.Otitis media among children in day care: epidemiology and pathogenesis. Rev Infect Dis 1986; 8: 533-538.
  9. Marchant CD, Shurin PA, Turezyk VA, Wasikowski DE, Tutihasi MA, Kinney SE. Course and outcome of otitis media in early infancy: a prospective study.J Pediatr 1984;104: 826-831.
  10. Wald ER, Guerra N, Byers C. Upper respiratory tract infections in young children: duration of and frequency of complications. Pediatrics1991; 87: 129-133.
  11. Leach AJ, Magrsc, Boswell JB, Asche V, Nienhuys TG, Mathews JD. Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian Aboriginal infants. Pediatric Infectious Disease Journal 1994; 13: 983-89.
  12. Dingle JH, Badger GF, Jordan WS Jr. Illness in the home: A study of 25,000 illnesses in a group of Cleveland families, Cleveland. Press of Western Reserve University, 1964; 347.
  13. Giebink GS. Childhood sinusitis: Pathophysiology, diagnosis and treatment. Pediatr Infect Dis J 1994; 13: S55-S65.
  14. Wald ER. Sinusitis in children. Pedirtr Infect Dis J 1988; 7: S150-S153.
  15. Ruggeri C, Barberio G, Pajno GB, Putorti A, Morabitol, Pollieino A, Febbraro R. Relationship between allergic rhinitis and otitis media with effusion:The role of the EustachianTube.Minerva Pediatr (Italy) 1990; 42: 481-483.

Correspondence:

Seema Sharma
C/O Dr. Vipin Sharma (Orthopedics)
Type 5, House No 23,Block B
Dr. Rajendra Prasad Govt. Medical College
Kangra (Tanda), HP 176001 India

E-mail:- seema406(at)rediffmail.com
Mobile- 09418455635

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