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Biomedical Research

Brief: Gastric relaxation by inhibitory neurotransmitters in hypertensive rats

Author(s): Keiichi Shimamura, Shinichi Kimura, Fumiko Sekiguchi, Satoru Sunano, Hideya Saito

Vol. 14, No. 1 (2003-01 - 2003-06)

Keiichi Shimamura, Shinichi Kimura, Fumiko Sekiguchi, Satoru Sunano, Hideya Saito

Correspondence to:

Dr. Keiichi Shimamura
Department of Clinical Pharmacology
Faculty of Pharmaceutical Sciences
Health Sciences University of Hokkaido
1757 Kanazawa
Ishikari-Tobetsu, Hokkaido 061-0293

Phone: +81-1332-3-1211 ext.3160 Fax: +81-1332-3-1669
e-mail: shimamu(at)

Nerve-mediated relaxations were compared in the gastric fundus of normotensive Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Previously, we examined postsynaptic responses to b-adrenoceptor stimulation using isoproterenol. In preparations from SHRSP, the amplitude of isoproterenol-induced relaxation and extent of membrane hyperpolarization were lower than preparations from WKY. In the present study, nitric oxide-mediated relaxation was evoked by electrical field stimulation (ES) at 0.7 Hz for 10 sec, in the presence of guanethidine and atropine. ES-evoked relaxation was abolished by inhibition of nitric oxide synthesis and the amplitude of relaxation did not differ between WKY and SHRSP. The amplitudes of relaxation induced by the nitric oxide donors, NOR 3 and sodium nitroprusside were similar in preparations from WKY and SHRSP. These results indicated that the postsynaptic response to β-adrenoceptor agonist stimulation, but not that to nitric oxide, was impaired in the gastric fundus of hypertensive rats.

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